{"id":7230,"date":"2020-01-20T15:32:50","date_gmt":"2020-01-20T18:32:50","guid":{"rendered":"http:\/\/tdibrasil.org\/?p=7230"},"modified":"2020-01-20T15:32:50","modified_gmt":"2020-01-20T18:32:50","slug":"o-que-e-a-hipotese-de-ajuste-molecular","status":"publish","type":"post","link":"https:\/\/tdibrasil.org\/index.php\/2020\/01\/20\/o-que-e-a-hipotese-de-ajuste-molecular\/","title":{"rendered":"O que \u00e9 a Hip\u00f3tese de Ajuste Molecular?"},"content":{"rendered":"
\"\"
Tinkering Hypothesis: “tinkering”, aqui “ajuste”, seria algo como arrumar, ajeitar, reparar de improviso<\/center><\/figcaption><\/figure>\n
\n

Por\u00a0Ashish Thakur <\/strong>(adapta\u00e7\u00e3o)<\/em><\/span><\/p>\n

Ajuste por defini\u00e7\u00e3o significa “fazer pequenas altera\u00e7\u00f5es em algo, especialmente na tentativa de repar\u00e1-lo ou melhor\u00e1-lo”<\/p>\n

Este conceito foi introduzido como uma conceitua\u00e7\u00e3o cient\u00edfica do “cavalo de batalha evolucion\u00e1rio” pelo Pr\u00eamio Nobel Fran\u00e7ois Jacobis. Leia o artigo original aqui<\/a>. A “n\u00edvel molecular”, ele sustentava que todos os organismos vivos tinham elementos unificados para trabalhar; os mesmos elementos de \u00e1cido nucleico, a mesma estrutura proteica, os mesmos biopol\u00edmeros etc. Al\u00e9m disso, a maioria dos processos realizados por bact\u00e9rias e homens s\u00e3o muito semelhantes, mas existe essa enorme complexidade em grande escala. Ele afirma que a complexidade da vida se desenvolveu a partir das mol\u00e9culas originais existentes.<\/p>\n

De uma maneira engra\u00e7ada, isso \u00e9 muito semelhante ao que Rudolf Virchow disse – “Omnis cellula e cellula” (Toda c\u00e9lula procede de outra c\u00e9lula). Como exemplo, voc\u00ea pode observar eventos de duplica\u00e7\u00e3o de genes e diverg\u00eancia. Os mesmos ingredientes b\u00e1sicos foram configurados e utilizados – da\u00ed manipulados – para produzir formas de vida modificadas. Se necess\u00e1rio, novas estruturas e fun\u00e7\u00f5es tamb\u00e9m podem resultar dessas varia\u00e7\u00f5es. Jacob afirma firmemente que “as mudan\u00e7as bioqu\u00edmicas n\u00e3o parecem, portanto, ser a principal for\u00e7a de diversifica\u00e7\u00e3o do organismo vivo. A parte realmente criativa da bioqu\u00edmica deve ter ocorrido muito cedo”<\/strong>.\u00b9<\/p>\n

Em suma, o repert\u00f3rio (e diversidade) de mol\u00e9culas complexas \u00e9 resultado da regula\u00e7\u00e3o, express\u00e3o e organiza\u00e7\u00e3o diferencial das mesmas estruturas qu\u00edmicas.<\/p>\n

Nota do tradutor \u00b9:<\/strong> Sobre esse padr\u00e3o universal, profundo e fixo que “surgiu muito cedo”, est\u00e1tico desde a origem, h\u00e1 o Argumento de Coer\u00eancia<\/a> onde exponho que a hierarquia de padr\u00f5es conservada, em alguns casos dita “congelada”, reflete uma arquitetura com presci\u00eancia de design e n\u00e3o o que esperar\u00edamos de um processo acidental ao longo do tempo (ancestralidade comum).<\/p>\n

\n

Original:\u00a0Ashish Thakur<\/strong>. What is molecular tinkering hypothesis?<\/a> Feb 22, 2016.<\/p>\n","protected":false},"excerpt":{"rendered":"

Essa hip\u00f3tese sustenta que os organismos vivos possuem elementos unificados. A maioria dos processos s\u00e3o muito semelhantes, as mudan\u00e7as bioqu\u00edmicas n\u00e3o parecem ser o principal fator de diversifica\u00e7\u00e3o.<\/p>\n<\/div>","protected":false},"author":1,"featured_media":7237,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,24,40],"tags":[479],"class_list":["post-7230","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bioquimica","category-genetica","category-traducao","tag-hipotese-de-ajuste-molecular"],"yoast_head":"\nO que \u00e9 a Hip\u00f3tese de Ajuste Molecular? » Portal TDI Brasil +<\/title>\n<meta name=\"description\" content=\"Essa hip\u00f3tese sustenta que os organismos vivos possuem elementos unificados. 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