{"id":5260,"date":"2019-02-07T02:54:34","date_gmt":"2019-02-07T04:54:34","guid":{"rendered":"http:\/\/tdibrasil.org\/?p=5260"},"modified":"2021-10-10T03:51:31","modified_gmt":"2021-10-10T06:51:31","slug":"mapa-subcelular-do-proteoma-humano-revela-arquitetura-altamente-complexa","status":"publish","type":"post","link":"https:\/\/tdibrasil.org\/index.php\/2019\/02\/07\/mapa-subcelular-do-proteoma-humano-revela-arquitetura-altamente-complexa\/","title":{"rendered":"Mapa Subcelular do Proteoma Humano Revela \u201cArquitetura Altamente Complexa\u201d"},"content":{"rendered":"<figure id=\"attachment_5261\" aria-describedby=\"caption-attachment-5261\" style=\"width: 660px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-5261\" src=\"https:\/\/tdibrasil.org\/wp-content\/uploads\/2019\/02\/proteome-architecture.jpg\" alt=\"\" width=\"660\" height=\"413\" \/><figcaption id=\"caption-attachment-5261\" class=\"wp-caption-text\"><center>Imagem meramente ilustrativa \/ \u00a9<\/center><\/figcaption><\/figure>\n<hr \/>\n<p>Por\u00a0<strong>Cornelius Hunter<\/strong><\/p>\n<p style=\"text-align: justify;\"><a href=\"https:\/\/science.sciencemag.org\/content\/early\/2017\/05\/10\/science.aal3321\" target=\"_blank\" rel=\"noopener noreferrer\">Uma nova pesquisa<\/a>\u00a0est\u00e1 usando anticorpos para mapear as localiza\u00e7\u00f5es espa\u00e7o-temporais de 12.003 prote\u00ednas diferentes em c\u00e9lulas humanas.\u00a0Os resultados s\u00e3o outro exemplo de como, como Bruce Alberts\u00a0<a href=\"https:\/\/darwins-god.blogspot.com\/2009\/09\/cellular-polarity.html\" target=\"_blank\" rel=\"noopener noreferrer\">colocou em 1998<\/a>: &#8220;N\u00f3s sempre subestimamos as c\u00e9lulas&#8221;.<\/p>\n<p style=\"text-align: justify;\">Alberts explicou como as c\u00e9lulas eram ingenuamente vistas como algo aleat\u00f3rio, onde se pensava que as mol\u00e9culas se difundiam livremente, colidindo aleatoriamente. A nova pesquisa revela a &#8220;arquitetura altamente complexa da c\u00e9lula humana&#8221; e acrescenta mais detalhes ao fato que o funcionamento da c\u00e9lula est\u00e1 longe de ser aleat\u00f3rio:<\/p>\n<blockquote class=\"tr_bq\">\n<p style=\"text-align: justify;\">Um total de 12.003 prote\u00ednas direcionadas por 13.993 anticorpos foram classificados em um ou v\u00e1rios dos 30 compartimentos e subestruturas celulares, definindo em conjunto os proteomas de 13 organelas principais.<\/p>\n<\/blockquote>\n<p style=\"text-align: justify;\">Embora os evolucionistas \u201c<a href=\"https:\/\/www.sciencedaily.com\/releases\/2007\/06\/070601072308.htm\" target=\"_blank\" rel=\"noopener noreferrer\">achassem que a c\u00e9lula era t\u00e3o simples<\/a>\u201d, esta pesquisa mostra que o \u201cproteoma celular \u00e9 compartimentalizado e espacialmente regulado em alto grau\u201d. De fato \u201c[mais de metade dessas 12.003 prote\u00ednas localizam-se em\u00a0<b>mais de um compartimento<\/b>\u00a0ao mesmo tempo.\u201d Isso \u00e9 consistente com o fato de que a\u00a0<a href=\"https:\/\/darwins-god.blogspot.com\/2013\/01\/genes-code-for-many-layers-of.html\" target=\"_blank\" rel=\"noopener noreferrer\">maioria das prote\u00ednas \u00e9 capaz de realizar m\u00faltiplas fun\u00e7\u00f5es<\/a>, e \u00e9 outro indicador de alta complexidade:<\/p>\n<blockquote class=\"tr_bq\">\n<p style=\"text-align: justify;\">Al\u00e9m disso, prote\u00ednas que se localizam em mais de um compartimento podem ter\u00a0<b>fun\u00e7\u00f5es espec\u00edficas ao contexto, aumentando a funcionalidade do proteoma<\/b>.\u00a0O fato de que as prote\u00ednas <em>tem uma segunda fun\u00e7\u00e3o<\/em> em diferentes partes da c\u00e9lula \u00e9 agora bem aceito.\u00a0\u2026 Quanto\u00a0<b>mais complexo \u00e9 um sistema, maior \u00e9 o n\u00famero de partes que devem ser mantidas em seu devido lugar e menor \u00e9 a toler\u00e2ncia a erros;\u00a0portanto, um alto grau de regula\u00e7\u00e3o e controle \u00e9 necess\u00e1rio<\/b>\u00a0.<\/p>\n<\/blockquote>\n<p style=\"text-align: justify;\">De fato, o grau de regula\u00e7\u00e3o e controle requerido para este sistema n\u00e3o \u00e9 apenas enorme, mas contr\u00e1rio \u00e0s expectativas evolucion\u00e1rias.<\/p>\n<hr \/>\n<p>Original: <strong>Cornelius Hunter<\/strong>. <a href=\"https:\/\/evolutionnews.org\/2017\/07\/subcellular-map-of-the-human-proteome-reveals-highly-complex-architecture\/\" target=\"_blank\" rel=\"noopener noreferrer\">Subcellular Map of the Human Proteome Reveals \u201cHighly Complex Architecture\u201d<\/a>. July 26, 2017.<\/p>\n","protected":false},"excerpt":{"rendered":"<div class=\"mh-excerpt\"><p>Por\u00a0Cornelius Hunter Uma nova pesquisa\u00a0est\u00e1 usando anticorpos para mapear as localiza\u00e7\u00f5es espa\u00e7o-temporais de 12.003 prote\u00ednas diferentes em c\u00e9lulas humanas.\u00a0Os resultados s\u00e3o outro exemplo de como, <a class=\"mh-excerpt-more\" href=\"https:\/\/tdibrasil.org\/index.php\/2019\/02\/07\/mapa-subcelular-do-proteoma-humano-revela-arquitetura-altamente-complexa\/\" title=\"Mapa Subcelular do Proteoma Humano Revela \u201cArquitetura Altamente Complexa\u201d\">[&#8230;]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":5261,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25,40],"tags":[170,781,782],"class_list":["post-5260","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-geral","category-traducao","tag-celula","tag-proteinas","tag-proteoma"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Mapa Subcelular do Proteoma Humano Revela \u201cArquitetura Altamente Complexa\u201d &raquo; 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